point-of-care microfluidics

; Choi, C.Y.C. ; Sinha, S.; Standeven, J.; Bhamla, M.S. ; Santamara, M.; Torrejn, M.J.; Gimnez, N. Prostate cancer screening: Guidelines review and laboratory issues. ; Hraha, T.; Russell, T.M. Kan, C.W. ; Shiesh, S.C.; Lee, G. Bin an integrated microfluidic system for measurement of glycated hemoglobin Levels by using an aptamer-antibody assay on magnetic beads. cTnI is the gold standard biomarker for the early diagnosis of AMI [, Boonkaew et al., developed a paper-based microfluidic that can simultaneously measure the levels of three essential CVD biomarkers: C-reactive protein (CRP), cTnI, and procalcitonin (PCT). Hu, J.; Cui, X.; Gong, Y.; Xu, X.; Gao, B.; Wen, T.; Lu, T.J.; Xu, F. Portable microfluidic and smartphone-based devices for monitoring of cardiovascular diseases at the point of care. ; Campbell, T.G. Chan, H.N. Early diagnosis can reduce mortality and total treatment costs for patients with CVDs [, The use of a single biomarker to diagnose CVD has some limitations, for example, a single biomarker may be associated with multiple diseases and may provide an incorrect diagnosis. Current microfluidic technologies can be combined with other medical detection technologies to achieve better detection results. Crosby, J.R.; Decook, K.J. ; Shu, Y.; Xiong, B.; Chen, Y.; Chen, Y.; Tian, Q.; Michael, S.A.; Shen, B.; Wu, H. Simple, cost-effective 3D printed microfluidic components for disposable, point-of-care colorimetric analysis. ; writingreview and editing, S.-M.Y. DNA methylation of tumor suppressor genes. Waheed, S.; Cabot, J.M. Park, S.; Zhang, Y.; Lin, S.; Wang, T.H. It is organized by diagnostic test category highlighting some key developments in the area. Deng, H.; Zhou, X.; Liu, Q.; Li, B.; Liu, H.; Huang, R.; Xing, D. Paperfluidic chip device for small RNA extraction, amplification, and multiplexed analysis. The color change induced by ZIKV RNA in the microfluidic detection area is observable within 15 min, and virus detection can be completed with a smartphone camera [, Human blood analysis yields important health information. ; Song, L.; Piech, T.; Patel, P.P. Chan, H.N. This research was funded by the National Natural Sciences Foundation of China (Grant No. ; Lange, P.H. ; Albert, M.A. Poverty is strongly related to chronic disease. The development of 3D printing technology has resulted in new methods of rapid POC detection [. Although digital ELISA can detect multiple protein markers simultaneously and can achieve a higher sensitivity compared with conventional ELISA, these detection methods often require nonportable instruments and are unsuitable for rapid detection, especially in underdeveloped regions. Reslova, N.; Michna, V.; Kasny, M.; Mikel, P.; Kralik, P. xMAP technology: Applications in detection of pathogens. Multiplex immunosensor arrays for electrochemical detection of cancer biomarker proteins. ; nal, B.; Khademhosseini, A.; Butt, H. Wearables in medicine. Paper-based microfluidic device using RT-LAMP. paper provides an outlook on future directions of research or possible applications. lvaro, S.; Marn, G.; Vincent, S.; Marn, .G. The developed platform has great potential for the early diagnosis of AMI. ; Hashim, U. Aptamer-based point-of-care testing. Microfluidic devices are considered mobile devices because a sample analysis can be performed entirely within the small, portable device [, A POCT is a portable device used for analysis and detection outside a conventional laboratory [, Microfluidic systems have had a substantial influence on the applications of POCTs in medical diagnosis. Dinter, F.; Burdukiewicz, M.; Schierack, P.; Lehmann, W.; Nestler, J.; Dame, G.; Rdiger, S. Simultaneous detection and quantification of DNA and protein biomarkers in spectrum of cardiovascular diseases in a microfluidic microbead chip. ; Rad, M.B. Martinez, A.W. Engvall, E.; Perlmann, P. Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G. Liu, H.; Lei, Y. ; Buroker, A.B. Raju, S.P. Karakaya, M. Analytical molecular diagnosis of cervical cancer via paper microfluidic chip. Specific substrates, such as ortho-phenyldiamine dihydrochloride, are used to hydrolyze through the top of the enzyme to produce colored results [, ELISA can also detect and analyze infectious pathogens such as viruses [, Conventional ELISA must be improved for it to obtain the high detection sensitivity necessary for protein detection [, On the basis of digital ELISA, Chang et al., proposed a theoretical model that generates signals as a function of time, concentration, and binding constant [. These detection methods must become more widespread, and a method to achieve this goal is microfluidic technologies. Microfluidic point-of-care testing: Commercial landscape and future directions. The importance of telemedicine technologies has been widely recognized during the COVID-19 pandemic, which has transformed the lifestyles of many people [, Many applications of telemedicine have been realized during the pandemic. ; Poon, L.L.M. ; Green, L.S. Tian, Y.; Zhang, T.; Guo, J.; Lu, H.; Yao, Y.; Chen, X.; Zhang, X.; Sui, G.; Guan, M. A LAMP-based microfluidic module for rapid detection of pathogen in cryptococcal meningitis. There are different types of microfluidic POC equipment, but in the final analysis, it can meet the low-cost real-time detection of different regional environments. Glycated Hb (HBA1C) is an essential diagnostic tool for detecting and managing patient conditions [, HBA1C is an essential parameter for indicating blood glucose levels and the monitoring of blood glucose levels is helpful for patients with diabetes, and can protect their internal organs [, Diabetic patients usually exhibit one or more complications, with hyperlipidemia being the most serious. ; Hsu, K.F. These diseases have a long duration, progress slowly, and do not spread from person to person. ; Kan, C.W. Finally, the current commercialization status of microfluidic devices is described and our opinions on the technology are given. ; Urban, G.A. Iha, K.; Inada, M.; Kawada, N.; Nakaishi, K.; Watabe, S.; Tan, Y.H. Ray, A.; Esparza, S.; Wu, D.; Hanudel, M.R. ; Goldberger, Z.D. Multiplexed point-of-care testingxPOCT. POC equipment has formed a large commercial scale and has been applied in different disease detection fields [. Rissin, D.M. The cost of each centrifuge is no more than USD 0.20, and the device is very small with a weight of only 2 g. It can reach speeds of 125,000 rpm for 30,000. Rapid low-cost microfluidic detection in point of care diagnostics. ; Khor, S.M. ; Auckland, K.; Baillie, J.K.; Barnes, E.; Beer, S.; Bell, J.I. Paper-based microfluidic device using colorimetry. The motion and precipitation of suspensoids in divergent electric fields. Glycogen phosphorylase isoenzyme BB (GPBB), cTnT, and CK-MB. Salivary diagnostics on paper microfluidic devices and their use as wearable sensors for glucose monitoring. Additionally, those in the microfluidic field should increase their investment in biomedical applications and attempt to increase the adoption of microfluidics in clinical trials. Paper microfluidics for nucleic acid amplification testing (NAAT) of infectious diseases. ; Mykhalovskiy, E.; Worthington, C.; Gmez-Ramrez, O.; Gilbert, M.; Grace, D. Pay to skip the line: The political economy of digital testing services for HIV and other sexually transmitted infections. This makes the detection techniques time-consuming, costly, and labor-intensive, limiting their applicability for early disease diagnosis [, For people in underdeveloped areas, the lack of medical resources is even more severe. ELISA is primarily a plate-based assay. ; Yip, C.C.Y. Rapid detection of novel coronavirus/Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by reverse transcription-loop-mediated isothermal amplification. Huang, X.; Li, Y.; Chen, J.; Liu, J.; Wang, R.; Xu, X.; Yao, J.; Guo, J. Smartphone-based blood lipid data acquisition for cardiovascular disease management in internet of medical things. Fabrication of microfluidic systems in poly(dimethylsiloxane). Burki, T. COVID-19 vaccine mandates in Europe. Mandal, N.; Pakira, V.; Samanta, N.; Das, N.; Chakraborty, S.; Pramanick, B.; RoyChaudhuri, C. PSA detection using label free graphene FET with coplanar electrodes based microfluidic point of care diagnostic device. ; Mun, B.; Huh, Y.M. Commercialization of microfluidic devices. Bircsak, K.M. Clinical features of 85 fatal cases of COVID-19 from Wuhan: A retrospective observational study. On-farm colorimetric detection of Pasteurella multocida, Mannheimia haemolytica, and Histophilus somni in crude bovine nasal samples. Wang, C.H. ; Bethel, C.; Hunt, C.; Gillen, S.; Moran, A.; Tesic, V. Evaluation of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies. ; Zheng, L.; DiazGranados, C.A. Squires, T.M. ; Khalpey, Z.I. Lim, J.; Kang, B.; Son, H.Y. and Y.C. The aim is to provide a snapshot of some of the most exciting work Tavakoli, H.; Zhou, W.; Ma, L.; Perez, S.; Ibarra, A.; Xu, F.; Zhan, S.; Li, X.J. Hyperlipidemia is a common chronic disease that may lead to CVD. ; Davies, E.V. Microfluidics and the related technologies are inexpensive, portable, and have sensitive detection; therefore, this technology can meet the requirements for medical testing in remote areas. ; Bachmann, T.T. Rissin, D.M. ; et al. Microfluidic POC devices have been successfully applied in infectious diseases detection, CVD detection, tumor detection, and chronic disease detection And the detection of diseases by microfluidic POC devices is typically achieved through the detecting of biomarkers and antibodies in serum. Carrilho, E.; Martinez, A.W. Bashshur, R.; Doarn, C.R. The statements, opinions and data contained in the journal, 1996-2022 MDPI (Basel, Switzerland) unless otherwise stated. Please note that many of the page functionalities won't work as expected without javascript enabled. A standalone micro biochip to monitor the cancer progression by measuring cancer antigens as a point-of-care (POC) device for enhanced cancer management. ; Brouland, J.P.; Leval, L. De Microfluidic-based immunohistochemistry for breast cancer diagnosis: A comparative clinical study. Microfluidics will play a vital role in the revolution in point of care diagnostics that is set to take place over the next decade. Becker, H. Hype, hope and hubris: The quest for the killer application in microfluidics. AI for infectious disease modelling and therapeutics. Yetisen, A.K. Kadimisetty, K.; Song, J.; Doto, A.M.; Hwang, Y.; Peng, J.; Mauk, M.G. Chen et al., introduced a microfluidic platform combining magnetic-based single bead trapping and acoustic micromixing that could detect many tumor biomarkers within minutes. ; Macdonald, N.P. Uddin, M.J.; Bhuiyan, N.H.; Shim, J.S. ; supervision, S.-M.Y. ; Wu, M.; Padhy, P.; Jensen, M.A. ; Mandal, D.; Zhuang, S.; Lee, E.S. Bioprinting is a promising method that can print organ structures to study underlying pathological mechanisms. Microfluidic systems have a high sensitivity and can obtain results rapidly; thus, microfluidic systems combined with POCTs are the most portable and least expensive devices for rapid detection [, The detection of biomarkers is key in medical detection. ; Chik, T.S.H. juncker david chip lab scales length rsc rapid diffusion canada microfluidics

Hong, Z.; Li, N.; Li, D.; Li, J.; Li, B.; Xiong, W.; Lu, L.; Li, W.; Zhou, D. Telemedicine during the COVID-19 pandemic: Experiences from Western China. ; Adams, A.N. ; Jin, G.J. The method uses a variety of enzyme substances, such as alkaline enzyme, horse radish oxidase and -galactosidase. The force leading to this motion is called a dielectrophoretic force [, Blood is mainly composed of plasma and cells, and there are a variety of cell types in blood. ; Li, K.H. ; Kang, T.; Moon, J.; Lee, J.J.; Seo, S.B. ; Butt, H.; Khademhosseini, A.; et al. ; Pai, M.; Gao, L. Application of artificial intelligence in digital chest radiography reading for pulmonary tuberculosis screening. Li et al., improved the system and designed a paper-based integrated diagnosis system. Chen, Q.; He, Z.; Mao, F.; Pei, H.; Cao, H.; Liu, X.

Single molecule enzyme-linked immunosorbent assays: Theoretical considerations. Cardiovascular disease in the developing world: Prevalences, patterns, and the potential of early disease detection. ; Preston, S.D. microfluidic; POC (point-of-care); medical testing; COVID-19; wearable devices; telemedicine, Applications of Biomedical Engineering in Dentistry, Int. The system used mathematical models to simulate real fluid control conditions, and Chen et al., demonstrated the platforms ability to quickly detect biomarkers, thus verifying the platforms ability to quickly detect multiple cancer biomarkers in future applications for POC diagnosis [, Microfluidic technology can simulate a tumor microenvironment on a chip to cultivate tumor cells and screen anti-cancer drugs on the chip, saving companies hundreds of millions of dollars in research and development funding. Ma, Q.; Ma, H.; Xu, F.; Wang, X.; Sun, W. Microfluidics in cardiovascular disease research: State of the art and future outlook. ; Ntogka, M.; Parasyris, K.; Theodosi, G.I. Al-Faqheri, W.; Thio, T.H.G. ; Chang, L.; Rivnak, A.J. The integration of microfluidics in medical point detection has significantly changed disease diagnosis and pathogen detection. Many possibilities exist for future uses of microfluidics for cancer detection including POC applications of exosomes, multiple cancer biomarker POC detection, tumor cell cultures, telemedicine, and anti-cancer drug screening on microfluidic chips. Due to the lack of timely medical services in underdeveloped areas, some diseases may develop into chronic diseases, or existing chronic diseases may be left undiagnosed or not be subject to proper treatment [, Chronic diseases include all health problems that must be continually managed for at least six months. Soft lithography for microfluidics: A Review. The social determinants of chronic disease. Mabey, D.; Peeling, R.W. With the development of micro manufacturing technology, cell separation and concentration based on DEP have become possible in practice and because DEP is simple to operate, does not need skilled technicians, has low voltage requirements and does not need high use requirements, DEP has the potential to be used in portable POC medical devices. The device has high sensitivity and specificity in isolating and detecting cancer-specific exosomes from patients urine. those of the individual authors and contributors and not of the publisher and the editor(s). Moreover, the dielectric properties of cells can be separated by Dep. A lifetime of insulin injections is required to control blood sugar. ; Blumenthal, R.S. Vishwanatham et al., developed a portable POC device that could be used for the ECG monitoring of rural residents. The device can be used as a supplement to current point-of-care and community testing procedures. Most protein biomarkers produced by the human body are released into the blood, urine, or other fluids and thus can be detected in these fluids [, Wearable devices may also become common in the POC detection of CVDs. ; Cherry, S.; Bau, H.H. Seshadri, D.R. The system effectively integrates the paperfuge and an immunoassay unit that can analyze biomarkers in blood while centrifuging. Advances in smartphone-based point-of-care diagnostics. The main components were made from silicon and glass by using photolithography and chemical etching technology [, Recently, cheap paper and three-dimensional (3D) printing technology have been used for microfluidic chip fabrication, reducing the cost of manufacturing [. ; Garca-Snchez, P.; Convine, N.; Rosser-James, A.; Tyler, M.; Bandoo, K.; et al. ; et al. DEP is a phenomenon of relative motion between suspension and medium under a non-uniform electric field. System integrating dielectrophoresis (DEP), graphene field-effect transistors (FETs) and a compact discbased microfluidic.

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