Avoid or Use Alternate Drug. Monitor Closely (1)epinephrine and fluoxetine both increase QTc interval. Contraindicated. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)papaveretum increases and epinephrine decreases sedation.
Modify Therapy/Monitor Closely. Other (see comment). Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Monitor Closely (1)tolvaptan increases and epinephrine decreases serum potassium. Monitor Closely (2)esmolol decreases effects of epinephrine by pharmacodynamic antagonism. lofepramine increases and epinephrine decreases sedation. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. carvedilol increases and epinephrine decreases serum potassium. Monitor Closely (1)benperidol increases and epinephrine decreases sedation. Minor (1)sage increases and epinephrine decreases sedation. Contraindicated. Avoid or Use Alternate Drug. epinephrine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Modify Therapy/Monitor Closely. and formulary information changes. epinephrine and dextroamphetamine both decrease sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. The above information is provided for general Monitor Closely (1)olanzapine increases and epinephrine decreases sedation. Use Caution/Monitor. Risk of hypertension and bradycardia. nortriptyline increases and epinephrine decreases sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. diphenhydramine increases and epinephrine decreases sedation. Monitor Closely (1)ethanol increases and epinephrine decreases sedation. Avoid or Use Alternate Drug. Monitor Closely (1)epinephrine increases effects of indacaterol, inhaled by Other (see comment). Avoid or Use Alternate Drug. Contraindicated (1)epinephrine increases toxicity of lurasidone by pharmacodynamic synergism. aripiprazole increases and epinephrine decreases sedation. tolvaptan increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Effect of interaction is not clear, use caution. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Caution is advised. Use Caution/Monitor. digoxin increases and epinephrine decreases serum potassium. levomilnacipran increases levels of epinephrine by pharmacodynamic synergism. Contraindicated. tolfenamic acid increases and epinephrine decreases serum potassium. Other (see comment). epinephrine and azithromycin both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor.epinephrine and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use this medication only if you have been told by your doctor that you have asthma. phenoxybenzamine, epinephrine. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Most automatic injection devices contain enough solution for one dose of epinephrine. Use Caution/Monitor.epinephrine and metaproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (2)betaxolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. epinephrine and erythromycin stearate both increase QTc interval. Consult your pharmacist or local waste disposal company. azelastine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. phenobarbital increases and epinephrine decreases sedation. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine and norepinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. morphine increases and epinephrine decreases sedation. amoxapine increases and epinephrine decreases sedation. Use Caution/Monitor. Monitor Closely (1)epinephrine decreases effects of insulin degludec/insulin aspart by pharmacodynamic antagonism. Monitor Closely (2)metoprolol decreases effects of epinephrine by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Monitor Closely (1)quazepam increases and epinephrine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. epinephrine and dronedarone both increase QTc interval. Monitor Closely (1)epinephrine and bumetanide both decrease serum potassium. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor.epinephrine and propylhexedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. Use Caution/Monitor. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. Effect of interaction is not clear, use caution. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Effect of interaction is not clear, use caution. metoprolol increases and epinephrine decreases serum potassium. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)temazepam increases and epinephrine decreases sedation. only. atomoxetine, epinephrine. Monitor Closely (1)carbinoxamine increases and epinephrine decreases sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. epinephrine and epinephrine racemic both decrease serum potassium. dopexamine and epinephrine both decrease serum potassium. epinephrine and droxidopa both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Avoid or Use Alternate Drug. ephedrine and epinephrine both decrease serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Serious - Use Alternative (1)epinephrine and clarithromycin both increase QTc interval. Effect of interaction is not clear, use caution. Use Caution/Monitor. epinephrine and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Other (see comment). Effect of interaction is not clear, use caution. meperidine increases and epinephrine decreases sedation. Use Caution/Monitor.epinephrine and formoterol both decrease sedation. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxapram increases effects of epinephrine by pharmacodynamic synergism. Use Caution/Monitor.Minor (1)thiothixene decreases effects of epinephrine by pharmacodynamic antagonism. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. epinephrine and fluphenazine both increase QTc interval. Monitor Closely (1)epinephrine and methyclothiazide both decrease serum potassium. epinephrine and formoterol both decrease serum potassium. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Use Caution/Monitor.lofepramine increases effects of epinephrine by unknown mechanism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Monitor Closely (1)topiramate increases and epinephrine decreases sedation. Serious - Use Alternative (1)epinephrine and lumefantrine both increase QTc interval. Risk of acute hypertensive episode. Do not puncture the canister or expose it to high heat or open flame.
Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. fluphenazine increases and epinephrine decreases sedation. epinephrine and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Risk of hypertension and bradycardia. cyproheptadine increases and epinephrine decreases sedation. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor.trimipramine increases effects of epinephrine by unknown mechanism. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Coadministration may reduce nateglinide's hypoglycemic action. Training devices are available to practice how to use the automatic injection device during an emergency. Use Caution/Monitor. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Contraindicated.
Serious - Use Alternative (1)levomilnacipran increases levels of epinephrine by pharmacodynamic synergism. atenolol increases and epinephrine decreases serum potassium. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Contraindicated. parecoxib increases and epinephrine decreases serum potassium. Monitor Closely (1)epinephrine and telavancin both increase QTc interval. Use Caution/Monitor.epinephrine and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Monitor Closely (1)epinephrine and dolasetron both increase QTc interval. Mechanism: pharmacodynamic synergism. Effect of interaction is not clear, use caution. Monitor Closely (2)epinephrine and dexfenfluramine both decrease sedation. epinephrine and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)primidone increases and epinephrine decreases sedation. Only a healthcare provider should give more than 2 injections for a single allergic episode. Use Caution/Monitor. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)naproxen increases and epinephrine decreases serum potassium. Other (see comment). epinephrine and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Effect of interaction is not clear, use caution. Monitor Closely (1)phentolamine, epinephrine. Effect of interaction is not clear, use caution. Limit alcoholic beverages. Avoid or Use Alternate Drug. What side effects can this medication cause? Note: Ratio expression of epinephrine concentrations are prohibited on drug labels; however, some may remain in inventory (1:1000 = 1mg/mL; 1:10,000 = 0.1mg/mL), During a resuscitation effort, 0.5 mg (5 mL) IV q5min, Intracardiac injection if there has not been sufficient time to establish an IV route, Usual dose ranges from 0.3-0.5 mg (3-5 mL), Alternatively, if the patient has been intubated, epinephrine can be injected via the endotracheal tube directly into the bronchial tree at the same dosage as for IV injection, 2-2.5 mg q3-5min until IV/IO access established or spontaneous circulation restored, 0.1 mg IV at rate of 1-4 mcg/min over 5 min to prevent the need to repeat injections frequently OR may initiate with infusion at 5-15 mcg/min (with crystalloid administration); IV administration should only be done in patients who are profoundly hypotensive or are in cardiopulmonary arrest refractory to volume resuscitation and several epinephrine injections, 0.3-0.5 mg (0.3-0.5 mL) of undiluted epinephrine IM/SC once in anterolateral aspect of the thigh, not to exceed 0.5 mg (0.5 mL) per injection, repeated every 5-10 minutes as necessary, Monitor clinically for reaction severity and cardiac effects, 0.3 mg (contents of 1 autoinjector) SC/IM once in anterolateral aspect of the thigh; may repeat dose after 5-15 minutes if symptoms persist, Dilute 1 mg (of 1 mg/mL single-use solution) to 1-10 mcg/mL, Dilute 1 mg (of 1 mg/mL single-use solution) to 2.5-10 mcg/mL, With severe persistent anaphylaxis, repeat injections with an additional autoinjector may be necessary, More than two sequential doses of epinephrine should only be administered under direct medical supervision, 0.15mg/0.15mL (EpiPen Jr, Auvi-Q, Symjepi), <30 kg (66 lbs): 0.01 mg/kg (0.01 mL/kg) SC/IM, not to exceed 0.3 mg (0.3 mL) per injection, repeated q5-10 min as necessary, 30 kg (66 lbs): 0.3-0.5 mg (0.3-0.5 mL) SC/IM, not to exceed 0.5 mg (0.5 mL) per injection, repeated q5-10 min as necessary, May repeat dose after 5-15 minutes if symptoms persist, Infants weighing 7.5-15 kg (16.5-33 lb); Auvi-Q only: 0.1 mg SC/IM once, Weight 15 to <30 kg: 0.15 mg (contents of 1 autoinjector/prefilled syringe) SC/IM once; may repeat dose q5-15min, Weight 30 kg: 0.3 mg (contents of 1 autoinjector/prefilled syringe) SC/IM once; may repeat dose q5-15min, 0.1 mg/mL solution: 0.01 mg/kg (0.1 mL/kg) IO/IV; not to exceed 1 mg/dose, May repeat q3-5min until return of spontaneous circulation, 1 mg/mL solution: 0.1 mg/kg (0.1 mL/kg) endotracheal; not to exceed 2.5 mg/dose, May repeat every 3-5 minutes prn until IV/IO access established, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol, To prevent sloughing and necrosis in areas has extravasation, infiltrate the area with 10-15 mL of 0.9% NaCl solution containing phentolamine 5-10 mg, Use a syringe with a fine hypodermic needle, with solution being infiltrated liberally throughout the area, which has a cold, hard, and pallid appearance, Phentolamine may cause immediate and conspicuous local hyperemic changes if area is infiltrated within 12 hr, Injection into buttock may not provide effective treatment of anaphylaxis, Accidental injection into hands, digits, or feet may result in local reactions including injection site coldness, pallor, and hypoesthesia or injury resulting in bruising, discoloration, erythema, bleeding, or skeletal injury, To minimize the risk of injection-related injury when administering autoinjector to children or infants, instruct caregivers to firmly hold childs leg in place and limit movement prior to and during injection, Coadministration with cardiac glycosides, diuretics, or anti-arrhythmics should be observed carefully for the development of cardiac arrhythmias, Effects of epinephrine may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine, Cardiostimulating and bronchodilating effects of epinephrine are antagonized by beta-adrenergic blocking drugs, such as propranolol, Vasoconstricting and hypertensive effects of epinephrine are antagonized by alpha-adrenergic blocking drugs, such as phentolamine, Ergot alkaloids may reverse the pressor effects of epinephrine, Epinephrine usually inhibits spontaneous or oxytocin-induced contractions of the pregnant human uterus and may delay second stage of labor; avoid epinephrine during second stage of labor; in dosage sufficient to reduce uterine contractions, the drug may cause a prolonged period of uterine atony with hemorrhage, Avoid epinephrine in obstetrics when maternal blood pressure exceeds 130/80 mmHg; although epinephrine may improve maternal hypotension associated with septic shock and anaphylaxis, it may result in uterine vasoconstriction, decreased uterine blood flow, and fetal anoxia, Store at room temperature, 20-25C (68-77F), Protect from light until ready to use; do not refrigerate; protect from freezing, Protect from alkalis and oxidizing agents, Store at room temperature (25C) or refrigeration (4C) is 24 hr, Store at room temperature 20-25C (68-77F); excursions permitted to 15-30C (59-86F; do not refrigerator, The trainer for AUVI-Q should not be used at temperatures <50F (10C) or >104F (40C), Store the trainer for AUVI-Q in its outer case; keep away from dirt, chemicals, and water. 
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