The week before it began I had some cramping and spotting. I had been on natural progesterone for a while and my symptoms only got worse after the DIM. And thats where DIM comes in. . It also makes you have a period if you're not pregnant. Perimenopause is the period between a womans later reproductive years and menopause. Thomson CA, Chow HHS, Wertheim BC, et al. Depending on your flow this could be two or three times a day. Men also benefit from DIM. The DIM compound may have several estrogen-related effects in your body: Helps prevent the effects of estrogen on cells. People who use the DIM supplement as part of a weight-loss regimen might expect to see effects in six weeks to six months. While in perimenopause, a womans progesterone levels will begin to decline as her ovulation is less regular. Calcium D-glucarate helps the body safely remove excess hormones, supports detoxification, and may be protective against certain cancers. At most cases, blood or urine is tested in a doctors office or lab. Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. Reply. Many factors influence how you are diagnosed with diabetes. Now, I just want to clear something up. By modulating estrogen and estrogen metabolism, DIM may help women with various hormonal difficulties. DIM may also cause tumor cells to self-destruct, assisting in the removal of excess estrogen from the body. Copy and paste it, adding a note of your own, into your blog, a Web page, forums, a blog comment, At the end there was about 5 days of spotting. annoying but tolerable. I also felt the same. Given that estrogen plays an important role in regulating fat accumulation, DIM supplements may aid weight loss although no human research currently supports this effect. An increasing amount of people are taking DIM supplements to help with issues like acne, premenstrual syndrome (PMS), weight loss and maybe even cancer. DHT is the form of testosterone associated with prostate cancer in men and conditions like hirsutism (hair where you dont want it) and acne in women. They are responsible for producing estrogen and regulating the menstrual cycle. In this way, diuretics help . DIM may also have an impact on your menstrual cycle. The other metabolites, 4OHE1 and 16OHE1 are associated with unfavorable growths of breast and uterine tissue, including cancer. Thanks. Researchers concluded that, in women taking tamoxifen, DIM promoted healthier estrogen metabolite production. Read more about supplements for PMS here. I know estrogen is often demonized, but we need estrogen! DIM has shown to have a number of health benefits. I'm also taking a b complex, iron and DIM supplements for estrogen issues. It's important to listen to your body and be kind to yourself during your cycle - so if you're feeling a little heavier but still want a bath, the option to wear a tampon is there. Stay hydrated: Drinking plenty of water can help lighten your flow and reduce your chances of leakage. I was so bloated. Taking DIM in high amounts can cause adverse side effects such as vomiting, headaches and nausea. Women with PCOS often have hormonal imbalances that cause hirsutism (unwanted hair growth on the face and body) and acne. In Phase 2 detox these metabolites are methylated and prepared for excretion via the kidneys and bowels. Although research is ongoing, increasing the ratio of 2-hydrozyestrone to 16-hydrozyesterone may reduce breast cancer risk and cause anti-tumor effects (8). #2. However, these are all side effects and not risks to your health.if(typeof ez_ad_units != 'undefined'){ez_ad_units.push([[300,250],'staminacomfort_com-medrectangle-3','ezslot_1',118,'0','0'])};__ez_fad_position('div-gpt-ad-staminacomfort_com-medrectangle-3-0'); Women who are using DIM as part of their birth control regimen should not use more than 5 mg of the supplement daily, and those who are pregnant or nursing should not use this amount at all. But I think if you take DIM all days it can also increase your testosterone levels. Don'ts DIM supplements also skip the entire process of converting it to its active form and deliver the specific nutrient. A.. Estrogen and Bone Health in Men and Women. Made from non-GMO-certified soybeans, this product is a plant-based source of phytoestrogens to provide holistic supplementation for a . As suggested, I increased my Cal D Gluarate and NAC to 2000mg. If you have or suspect that you have a medical problem, contact your health care provider promptly. I felt the slightest difference. The most common side effects include darkening of the urine, an increase in bowel movements, headaches, and gas (3, 8). Although this web site is not intended to be prescriptive, it is intended, and hoped, that it will induce in you a sufficient level of scepticism about some health care practices to impel you to seek out medical advice thatis not captive to purely commercial interests, or blinded by academic and institutional hubris. Left untreated, these conditions can progress and require surgery. This can help prevent headaches and other unwanted issues that can arise when using a Phase 1 nutrient alone. Being overweight increases your risk of experiencing irregular periods. Chewing cruciferous vegetables like broccoli, plant enzymes release DIM into your system. See what's being discussed, ask for help, give your thoughts or experiences, or just browse Its free and will bring you important new information on progesterone therapy and related health matters, Home|Contact|Newsletter|Index of Symptoms|News|Progesterone cream|Privacy policy|Blog|About|FAQ. Dry skin is one sign of low estrogen. DIMis a compound that can only be made from cruciferous vegetables. About one-fourth of the women experienced an increase in bowel frequency, while 18 percent had headaches or gas. Low estrogen is typically seen in younger women and women approaching menopause. Additionally, DIM has been shown to inhibit an enzyme called aromatase, which converts testosterone to estrogen (1). 2005 - 2023 WebMD LLC. The most favorable of the three is 2OHE1. This is why I felt DIM was the culprit. In cases of microbial dysbiosis in the gut it is possible for an enzyme known as betaglucuronidase to reactivate the metabolites created in the liver and put estrogen back into circulation. Which Supplement Has Been Shown To Repair Connective Tissue? I was wondering if I was still feeling the effects of the DIM. Do not disregard professional medical advice or delay in seeking professional advice because of something you have read on this web site. DIM supports liver enzymes that may help with Phase 1 estrogen metabolism, which is the phase that packages hormones and toxins up for elimination. Cauley, J. I was so happy that I didn't have to take mounds of ibuprofen, especially with all the new heart attack warnings. It contains ingredients that support Phase 1 and 2 estrogen metabolism in the liver, as well as calcium d-glucarate to ensure the body is able to safely remove estrogen from the body. I began using about 60mg. In place of supplements, include cruciferous vegetables in your diet. DIM is generally well-tolerated with a few mild symptoms for a few days. DIM supplements are purported to aid other hormone-related conditions. Those given DIM experienced significant improvements in prostate health, as well as PIN (14). It was not a great period but definitely better! Hi Im a 21 year old male, I started taking progesterone in September of this year as a supplement to my trt regime (cancer survivor under doctor supervision). Furthermore, DIM supplements may stimulate fat breakdown and inhibit fat cell formation. Try diuretics. But as you said, it is not necessary to keep it in my regiment either way. Can I open the DIM capsule? Symptoms of detoxification should only last three to seven days. It was the first one that I didn't actually have any leaks. According to studies, 30 mg of absorbable DIM per dosage is the most effective quantity of supplementary DIM, with daily doses of 60 mg for women and 120 mg for men. For severe ovulation pain, talk to your provider about options such as birth control pills. If no other issues arise, I will take it it was from the DIM. September 1, 2019 at 8:39 am. I just turned 47 and my cycles which used to be 28 days are now creeping down to 22-25 days. You are encouragedto refer any health problem to a health care practitioner and, in reference to any information contained in thisweb site, preferably one with specific knowledge of, Join in and write your own page! The use of any information provided on this web site is solely at your own risk. Towards the end of jan. 2015 I began Natpro and upped it to around 80mg. The first period I had was very slightly better. If you have ovulation pain, also called mittelschmerz, you may experience twinging or cramps during ovulation. All About Natural and Pharmaceutical Estrogen Blockers for Males, Our Favorite Healthy Finds: Organic Beauty Products for Acne-Prone Skin, The 12 Best Collagen Supplements for Better Skin. However, menstrual cycles tend to shorten and become more regular as you age. Dr. Brighten is an international speaker, clinical educator, medical advisor within the tech community, and considered a leading authority on womens health. DIM is supposed to help regulate estrogen levels in the body, while research on it is relatively restricted ( 1 ). The recommended dosage of myo-inositol for most women with PCOS is 4000 mg/day taken in two doses. She is a member of the MindBodyGreen Collective and a faculty member for the American Academy of Anti Aging Medicine. DIM stimulates the body to . Whiteley J, Dibonaventura MD, Wagner J-S, Alvir J, Shah S. The Impact of Menopausal Symptoms on Quality of Life, Productivity, and Economic Outcomes. Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis. For example, to obtain the dosage of 100300mg of DIM recommended for women, youd need to eat a lot more broccoli and cabbage than you might want to. The ovaries are a vital part of our body that play a role in women's reproductive capabilities. My April period was miserable a week late, horrible PMS emotional and physical and painful and 2-3 days of super heavy bleeding instead of 1-2 days. Supplements work gently and gradually, so they must be taken every day throughout the month not just during your period. The advised dosage of 100 to 200 mg of DIM per day for women and 200 to 400 mg of DIM per day for men in the book All About DIM refers to milligrams of such an absorbable formulation. Although there is research and anecdotal evidence to suggest benefits, it is important to note that more data is needed. It breaks the glucoronide bond between a toxin and glucuronic acid, and releases carcinogens, toxins and excess steroid hormones back into circulation. In the pilot study I mentioned first, urine analysis showed that DIM regulated estrogen metabolism in patients. I've had a Thyroidectomy 7 years ago. I guess it just puzzles me that I had been taking the Pr for months and didn't feel bad until the DIM. However, a study in 24 healthy people found that although DIM doses of up to 200 mg were well tolerated and didnt cause side effects, one person experienced nausea, headache, and vomiting after taking a 300-mg dose, suggesting that higher doses may be associated with adverse side effects (15). Aim to exercise most days of the month. Intriguingly, observational studies associate high cruciferous vegetable intake with a reduced risk of certain cancers, including breast and prostate cancer. Progesterone also stabilizes the HPA (adrenal) axis and supports thyroid function. I3C is found in cruciferous vegetables, such as: You will not get as much DIM from a vegetable as you would from a capsule. PMS symptoms are worsening. Q: I am worried about taking DIM because I don't want it to lower my estrogen levels. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Due to limited research, proper dosages for DIM are unknown. My main reason for seeking out progesterone was to help with the heavy periods I get every month. Should I keep taking it? If you have regular periods, take five days off from the first day of your period (day 1 to 5). Ugh!! Posted on Thursday, August 14, 2014 The majority of this article is information obtained from the book "All About DIM" by Michael A. Zeligs, MD and A. Scott Connelly, MD. Research also shows promising anti-tumor activity of DIM.1 Diindolylmethane (DIM . Diindolylmethane, or DIM for short, is a plant indolea plant compound with health-promoting properties. Saliva tests are simple to do at home. Any advice? I began taking around 80 mg a day. John Staughton is a traveling writer, editor, publisher and photographer with English and Integrative Biology degrees from the University of Illinois in Champaign-Urbana (USA). Each of these doses contains 2000 mg of myo-inositol and 50 mg D-chiro inositol. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. The only hormone metabolites known to help with appropriate levels of the free form of testosterone are the 2-hydroxy metabolites of estrogen induced by DIM. You take this pill every day at the same time. Bones that are weak or fragile. Poor nutrition and lack of exercise can also cause ovarian dysfunction. My May period came on day 23 (not great but more the norm for me) and my breasts were not as sore. All rights reserved. 3. Before using DIM, those who are at a greater risk for estrogen-sensitive malignancies other hormone-related diseases should talk to their doctor. Hello pls pass on this message to as many women as you can - heavy bleeding with fibroids - just take VIT B6 100 gms daily - if periods are heavy take VIT B6 either 50g mg and 50 mg Am and Pm - VIT B6 halts minimizes bleeding and prevents spotting - also load up on progesterone rich foods but VIT B6 is a simple over the counter that . Some individuals may benefit from taking 600 mg of diindolylmethane daily. I asked about natural progesterone and she said it wasn't strong enough. I recently ran out of the DIM and noticed my night sweats went away on day 2 of not taking them. There is also data to support its benefits in certain cancers. I have my fingers crossed that it will be even slightly lighter than it has been. For fertility: begin taking the herb regularly (daily) three months before you'd like to conceive. :))))). This is a very common condition that affects the health of women all over the world (often unknowingly). Simply click here to return to, Early pregnancy, estrogen dominance symptoms, Thyroidectomy & Progesterone effects on TSH, T4 and T3, Creative Commons Attribution 3.0 Unported License. In people with diabetes, this insulin response is not adequate. This is harmless and will go away once you stop taking DIM. 6. Then it began heavy with clotting, but not as bad as it usually is. Estrogen dominance could unfortunately come about for various reasons: anovulation (no ovulation), stress, adrenal issues, excess fat in the body, the environment, digestive problems, and autoimmune conditions. It's easy to do. I shared my protocol so you don't have to do the hours of research if facing any form of surgery. After reading reviews from people, there were a couple that were post menopausal but started having periods again due to the hormonal changes from taking the DIM. Maybe I needed some time to adjust to it but I was sooo miserable that I didn't want to chance waiting it out. DIM alters estrogen metabolism in a beneficial way, producing more good estrogens and fewer harmful estrogens. There is also data to support its benefits in certain cancers. For people weighing over 200 lbs, take 2 Diatom Rx capsules per day. DIM-plus contains diindolylmethane, a phytonutrient found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale. Altering those levels by taking DIM is dangerous for you both. Learn more about Balance Womens Hormone Support. "I would say about 10% of my clients who have used DIM see a change in their menstrual . Diindolylmethane (DIM) is a metabolite of Indole-3-carbinol (I3C), a compound found in cruciferous vegetables including broccoli, cabbage, and cauliflower.It is the most studied of all I3C metabolites and is thought to be superior to IC3 as a chemoprotective compound for breast cancer and prostate cancer .. It is a form of long-term birth control and also reduces or eliminates monthly bleeding. The when to take dim during cycle is a question that many women have. You only need a bathroom during dusk till dawn with no restrictions on eating or drinking. To understand how DIM supports your estrogen we first have to understand how estrogen is metabolized. While subjective, on. Incidentally, using pads for urinary incontinence has helped a little. After two weeks of supplementation, the ratio of 2OHE1 (the more beneficial estrogen metabolite) to 16OHE1 (a metabolite associated with the growth of tissue) increased, which is a shift in the right direction. A study published in 2014 found that the outcome of DIM interacting with hormones and genes may be good or bad, depending on the amount of hormones and DIM in the body. Perimenopause occurs between the ages of 40 and 50. If you're experiencing heavy periods, here's one supplement you could start taking that will help heal the issue alongside other dietary changes: Vitamin C with Bioflavonoids - 2,000-4,000 mg/day - has an anti-estrogenic effect on the uterus. People also ask, When should I take DIM morning or night? Try some relaxation methods. Hopefully this will make a difference. Eating a diet rich in cruciferous vegetables may supply you with the DIM your body needs to support healthy estrogen metabolism. For others, periods become significantly lighter. Your doctor can decide whether you need to switch to a different drug while taking DIM. Taking a collagen supplement can be an easy and effective way to help support better skin. DIM may help your body maintain healthy testosterone levels. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment, Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or homeopathic supplement, or using any treatment for a health problem. DIM at 10mg/kg also lowered the number of . As DIM supplements interact with estrogen levels, they may affect people with hormone-sensitive cancers or who are on hormone therapies. If you are struggling with heavy periods, tender breasts, mood swings, hot flashes and water retention, there is a high chance that you are estrogen dominant. Its important to support the entire system of estrogen metabolism. Its also concentrated and sold as a supplement. After one year of DMPA injections, 50% to 75% of women report having no periods. The third, Hello, i 25 years old and am taking 400 mg of Progesterone since 8 months and a lot of my many symptoms improved but I also didn't have a period since. A few clinical trials have shown that it supports healthy estrogen levels, lowering the risk of certain cancers and diseases like lupus that are linked to estrogen. The way that DIM gets into your system is an interesting process. Fortunately, there are steps that you can take to reduce period bloating, which include: 3. I stopped the DIM right after. A 30-day study in 19 post-menopausal women with early-stage breast cancer found that taking 108 mg of DIM per day also resulted in beneficial changes in estrogen levels (9). Im 50 years old and thought maybe I was starting to go into menopause. Dietary deficiencies and excessive amounts of toxins found in some foods can damage the ovaries over time. DIM has the potential to alter your menstruation since it changes your estrogen levels. Be selective with your sex toys. Even though diming out is not recommended as a form of treatment, it cannot hurt you either. No matter your medical history, its important to consult your healthcare provider before taking these supplements. Studies have shown that women in perimenopause and menopause experience a reduced health-related quality of life, as well as higher work impairment. I just turned 47 and my cycles which used to be 28 days are now creeping down to 22-25 days. I had some tests done at the gyn and she told me I had fibroids, possible adenomysis and that my lining was out of phase (she didn't clearly explain what that meant. Physical activity: Getting regular physical activity has been proven to relieve PMS symptoms like bloating. Because it helps regulate estrogen, DIM is a great supplement to look into for women experiencing PMS and period problems (such as cramps and heavy periods), especially when combined with nutrients like calcium and herbs like Vitex. My period is 2 days late, and it never is normally late. So DIM may not have much benefit. For most women, 3-5 milligrams is a safe dose of DIM; higher doses may cause unwanted side effects. The most common side effect was darkening of the urine. Your menstrual cycle might be regular about the same length every month or somewhat irregular, and your period . I had stopped taking it and done more research into DIM. Her work has been featured in the New York Post, Forbes, Cosmopolitan, Huffington Post, Bustle, The Guardian, Sports Illustrated, Elle, and ABC News. You may think of estrogen as only a female hormone, but its not. The good news is that you dont always need to rely on painkillers or the pill as the only treatment for these conditions. DIM and other plant indoles are found in . The week leading up to my period was so painful. What type of iodine do you take? Calcium d-glucarate mitigates the effect of betaglucuronidase. Last medically reviewed on July 22, 2020. Side effects of DIM include: Headache; Fatigue; Brain fog; Dark urine (pink to orange to brownish) The consensus is that darkened urine is harmless and will return to normal once you stop taking your DIM supplement. So if you take DIM during your period time and start BO with Vitex it helps a lot. Testosterone is an androgen that controls and governs masculine features such as male genital development, a deeper voice, and the distribution of body hair.